A Novel an All-Optical Refractive Index Biosensor Based-on Glass Cylinder Cavity Resonance for Detection of Malaria-Infected Red Blood Cells

Document Type : Original Article


School of Medicine, Case Western Reserve University, Cleveland OH 44106, USA


Malaria mosquitoes are abundant in most countries with warm climates, so malaria disease spreads rapidly through the bites of these mosquitoes to the human body. The effects of these diseases are very dangerous and deadly. Early detection of such diseases is very important to prevent death. In this paper, an all-optical biosensor based on the refractive index of healthy and infected samples in the human body is designed and presented. Many biosensors have been introduced in various ways in recent years, but optical biosensors based on two-dimensional photonic crystals (2D-PhCs) have received less attention for the detection of malaria disease. The proposed biosensor has a faster and more accurate detection than previous works. In addition, the sensitivity parameter is calculated as a percentage. The main function of the biosensor is based on the intensity of the signal transmitted from the input waveguide to the output waveguide. The higher the intensity of the received signal, the better for the person. The range of percentages is between 97% ~ 66.12% and the range of sensitivity is between 8.21RIU-1 ~ 11.91 RIU-1. In previous similar articles, sensitivity has not been calculated as a percentage, but here, due to showing the amount of sensitivity in different modes, the sensitivity parameter is defined as %RIU-1. The interaction of light with matter and samples of Maxwell's functional equations, and to obtain the output results in the software, the finite difference time domain method in two-dimensional is used. The overall dimensions of the proposed biosensor are very small and 57µm2, which reduces the time delay and increases the speed.